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I used to suffer from a debilitating and “incurable” disease called Fibromyalgia. After taking Exfuze Seven+ and Ester-C for several months, my condition improved substantially to the point that I can work full-time and lead a normal life. Here is my amazing testimony after getting back to normal for more than two years of suffering.

I was 33 years old when I was diagnosed with fibromyalgia. I was told by the rheumatologist that I would never be able to work again on a full time basis and that in a few years I may need help to take a bath or to take care of myself. I cried for sure but I decided that this was not going to be my life and that I would fight this.

I started a regular stretching and exercise program. I reduced my working hours by not doing any overtime work at night and I reduced my involvement in outside activities. I also started to take several anti-oxidant vitamins and minerals.

After six months on this health program, my condition did not improve. It actually continued to get worst to the point where I had to stop working in March 1998. As the fibromyalgia condition is considered incurable by the medical profession, I decided to consult Dr. Moore, a naturopath/homeopath (1) in 1999. I saw him every six weeks for approximately one year. I was again tested for food allergies and chemical sensitivities. I was given several vitamins and minerals, chinese herbs and homeopathic products with the purposes of detoxifying my body of various chemicals, boosting my immune system and various organs. I continued to follow my very strict diet and exercise program. I also started to do respiratory exercises twice a day. I received a few acupuncture treatments at that time without seeing much changes so I stopped these treatments.

The naturopath believed an immune system breakdown could have been the cause of my fibromyalgia because in the two years before the fibromyalgia condition came out, I had three respiratory infections, six colds and I got intoxicated with formaldehyde as I moved in a renovated office and in a new home. I also received a flu shot which had a very negative effect on my immune system. Also over the past twenty years, I had been working approximately 45-50 hours/week on a regular basis and been involved in various outside activities. Stress was part of my life and rest was not a priority because I never felt I needed a lot of it as I was so full of energy and had no sleep problems.

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I hope my testimony will be a source of encouragement to others who suffer from fibromyalgia. I know that this condition is quite debilitating as it affects all areas of your life: your working life, your family and social life, your finances etc. Learning to live with it is not easy but I believe there is hope. My condition did improve but it takes time. I know God has provided in nature with healing herbs and food, and throughout the past four years, I have asked God to guide me through this healing process. My trust is in the Lord and He gave me the discipline, the patience, the perseverance and the joy of waiting on Him through all this.

Hope this story helps others in pain and suffering from fibromyalgia.

Mary M.

Chronic Inflammation Linked to Cancer
Body’s Immune Systems Can Make Healthy Cells Change
Article date: 2002/06/06

The relationship between chronic inflammation and cancer gets a careful look in a report in the journal Oncology (Vol 16, No 2: 217-229).

Some cancers are known to occur more frequently in people with certain inflammatory diseases — like inflammatory bowel disease and hepatitis.

The authors believe an understanding of what is going on in the cells of these diseases may one day lead to better prevention and treatment for cancer.

There is much evidence that chronic inflammation leads to an increased cancer risk. The types of chronic inflammation that lead to cancer are varied. They are caused by things such as viruses, asbestos exposure, or even the body’s own digestive acids.

The longer the inflammation persists, the higher the risk of associated cancer.

“When people have a chronic inflammatory condition like inflammatory bowel disease, they have a five- to seven-fold higher incidence of colon cancer,” said lead author Emily Shacter, PhD, senior investigator at the US Food and Drug Administration (FDA). “The hypothesis is that it is our bodies’ own immune systems that are producing agents that cause cells in the colon to become cancer cells.”

Acute (short-term) inflammation is a good thing, as our bodies send cells or agents to deal with an infection or a foreign body, such as a splinter, said Shacter.

But chronic inflammation often has certain factors and pathways that, “in the wrong place and at the wrong time,” can encourage cancer growth, she said.

“It’s not easy to cause a cell to become cancerous,” Shacter said. “But if a certain sequence of events happens in such a way that a cell gets a growth advantage, it can go on to become a cancer cell. If we knew what was happening, we could possibly develop preventive strategies.”

Even in inflammatory conditions, cancer is still relatively rare.

“In our body we have about a million mutations a day,” said Michael Thun, MD, vice president of epidemiology and surveillance research at the American Cancer Society (ACS). “Most of them either get repaired or the cell commits suicide. It is only when a cell divides before it either repairs the DNA or commits suicide that the mutation becomes permanent.”

“Whether or not inflammation is providing the earliest mutations in cancer isn’t clear,” he said. “But what is clear is that it provides the conditions in which an abnormal cell and its progeny (offspring) can replicate and survive and accumulate more mutations to become an invasive cancer.”

Even so, Thun said, cancer “remains an uncommon event. Even in inflammatory conditions.”
Devising Treatments

Thun said what helps control inflammation may point scientists in the direction they need to go to either prevent cancer or stop its progression.

“One example has been the interest in NSAIDs with colon cancer,” he said. NSAIDs are non-steroidal anti-inflammatory drugs, such as aspirin or ibuprofen.

Shacter said another possible example now being explored is the role of oxidants — damaging substances produced by immune system cells — in inflammation and cancer.

While there’s not enough evidence to recommend them yet, “we may eventually start giving kids antioxidant compounds so that some tumor isn’t going to come up 20 years later,” Shacter said. “Or hopefully do something even more targeted than that. The more we understand about the basic science, the more we can design interventions and treatments.”

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Resveratrol may treat alcoholic liver disease

Wed Oct 22, 2008 10:39am EDT

NEW YORK (Reuters Health) – Resveratrol, an antioxidant abundant in grapes, red wine, peanuts — and, according to a new study, dark chocolate and cocoa — may prevent and treat the build-up of fat in the liver caused by chronic alcohol drinking.

In experiments with mice, resveratrol reduced the amount of fat produced in the liver of mice fed alcohol and increased the rate at which liver fat was broken down.

Chronic heavy alcohol drinking causes fat to accumulate in the liver and can lead to cirrhosis, fibrosis, and other liver diseases. “Our study suggests that resveratrol may serve as a promising agent for preventing or treating human alcoholic fatty liver disease,” the researchers conclude in a report in the American Journal of Physiology–Gastrointestinal and Live Physiology.

Previous work has shown that chronic alcohol ingestion inhibits two proteins — AMPK and SIRT1 — that play a key role in the breakdown of fats in the liver. When alcohol inhibits these two proteins, it allows fat to accumulate.

By activating AMPK and SIRT1, resveratrol helps to clear fat from the liver, the new study indicates.

In the study, mice were maintained on a low-fat diet and some were fed resveratrol alone, alcohol alone, or the combination of resveratrol plus alcohol.

Tests on the animals showed that resveratrol treatment boosted levels of SIRT1 and stimulated the activity of AMPK in the livers of mice fed alcohol. Increased expression and activity of SIRT1 and AMPK also fueled a reduction in the levels and activity of other liver proteins involved in fat buildup and boosted levels of the fat metabolizing hormone adiponectin.

Taken together, these results indicate that resveratrol prevents alcoholic fatty liver disease by coordinating molecules that control fat metabolism.

In a separate study published this month, researchers report that cocoa powder, baking chocolate and dark chocolate all contain significant levels of resveratrol.

“This study shows that the levels of resveratrol found in cocoa and chocolate products is second to red wine among known sources of resveratrol and forms yet another important link between the antioxidants found in cocoa and dark chocolate to other foods,” said Dr. David Stuart, director of natural product science at The Hershey Company who partnered with Planta Analytica to conduct the study.

SOURCE: American Journal of Physiology-Gastrointestinal and Liver Physiology 2008.

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Resveratrol Has Anti-aging and Anti-Cancer Properties, Linked to Cardiovascular Health

by Barbara L. Minton (see all articles by this author)

(NaturalNews) A wealth of new research findings continue to underscore the wonders of resveratrol, the compound discovered only a few years ago that has already achieved superstar status. Found predominately in red wine, grapes and peanuts, resveratrol is now showing to significantly impact the aging process, regulate for positive cardiovascular function, and protect against and reverse cancer.

Newest research finding

Researchers at Zhejiang University in China investigated the effect of injections of resveratrol on the central regulation of blood pressure, heart rate, and renal sympathetic nerve activity in animals. Their results suggest that resveratrol powerfully inhibits blood pressure, heart rate, and renal sympathetic nerve activity. This study has tremendous implications for anti-aging therapies.

In the July 26, 2008 Journal of Agriculture and Food Chemistry, researchers addressed the question of the potential chemo-preventative activity of resveratrol against human cancers and its effect on normal cells. They examined the differential effect of resveratrol at physiologically relevant concentrations on nonmalignant and malignant cell lines and compared the underlying mechanisms via cell cycle modulation, induction of cell death, and potential toxicity. They found that 24 hours of exposure to resveratrol was toxic to both nonmalignant and malignant cells in a dose dependent manner. However, nonmalignant cells re-grew 5 times more than malignant cells after 120 hours. Significant alterations in cell cycle kinetics were induced by resveratrol in the malignant cells, but to a lesser extent for the nonmalignant cells. The proportion of cell death was 3 times higher in malignant cells compared to nonmalignant cells.

This research confirms that resveratrol produces a selective action that is able to target malignant cells for destruction while allowing nonmalignant cells to modulate its effect. It is just this type of malignant cell action that chemotherapy aims to achieve. However, the effects of chemotherapy are also toxic to healthy cells.

Apoptosis, July 26, 2008 reports a search for compounds capable of protecting cells against deoxycholate, a bile salt that harms cells and causes disease. In colon epithelial cells, deoxycholate increased generation of reactive oxygen species and caused DNA damage and cell death. Resveratrol and also quercetin were each able to largely prevent the occurrence of cell death in cells exposed to deoxycholate. These findings suggest that resveratrol may be able to undo cellular damage that leads to colon cancer.

The July 9, 2008 Experimental Gerontology reports researchers finding that resveratrol is able to mimic the effects of rigorous calorie restriction in several cytoskeletal maintenance and multiple stress response pathways. This effect is achieved by control of mitochondrial biogenesis and turnover, critical factors in the maintenance of energy production, the prevention of endogenous oxidative stress, and the promotion of healthy aging. Previous research has revealed the healthy benefits associated with daily caloric restriction of between 30 and 50 percent below what is considered today as average. These benefits also occur as the result of fasting. Such diets have been linked to reduction in the risk of age associated diseases and stress, along with a slowing of age related functional decline. In a previous study, this research team found that consuming resveratrol improved the health and survival of obese mice, even while they continued to consume a high calorie diet. Resveratrol showed to have the same positive effect on the livers, muscles, hearts and bones as calorie restriction. Resveratrol has also been shown to extend the lives of yeast, worms, flies and fish.

In another study at Zhejiang University in China researchers investigated the effects of resveratrol on adenosine diphosphate (ADP)-induced platelet aggregation. Compared with the control group, resveratrol inhibited ADP-induced platelet aggregation and fibrinogen in a dose dependent manner. The accumulation of platelets can form clots which may result in heart attack by lodging in an artery and restricting blood flow to the heart or brain.

About resveratrol

Resveratrol’s most abundant source is the grapes used to make red wine, with the highest concentrations being found in the skins. Red wine contains approximately 160 micrograms per fluid ounce. Significant amounts of resveratrol are also found in peanut kernels, with one ounce of peanuts containing about 73 micrograms, the amount also contained in 6 cups of red grapes. It is a component of Ko-jo-kon, an oriental medicine used to treat diseases of the circulatory system, heart and liver. Since wine is the most notable dietary source, it is the primary object of speculation and research on resveratrol, although wine contains many other compounds with biologic effects.

Resveratrol’s properties as an antioxidant and anti-cancer agent are rapidly becoming documented, and it is sometimes referred to as an explanation for the “French Paradox”, the low incidence of heart disease in the French population who eat a relatively high fat diet. In grape and peanuts plants, resveratrol’s role is antibiotic and part of the defense system.

Other documented effects

Results from various research studies have shown resveratrol to be protective against the oxidation of LDL cholesterol in the blood. It is this oxidation of LDL that initiates the deposition of cholesterol in the walls of the arteries that can lead to heart attack. Its hydrophilic and lipophilic properties can provide more effective protection than other well-known antioxidants, such as vitamins C and E.

Research at the University of Illinois in Chicago using resveratrol extracted from grapes found that the threat of cancer was reduced in animals when the compound was used to stop the growth of damaged cells. Had these damaged cells been left to grow, they would have become out of control, resulting in cancer.

The Peanut Institute has concluded that the finding of resveratrol in peanuts may support epidemiological studies from Loma Linda University , Harvard School of Public Health and University of Minnesota that show peanuts may reduce the risk of heart disease by more than half when eaten frequently in small amounts.

Should you supplement with resveratrol?

Research on resveratrol is just beginning to reveal its array of health benefits, and many extracts of resveratrol are appearing on the market that make adding it to your diet very easy. Probably the best choice is to add a glass of red wine or peanuts to your diet. Both red wine and peanuts have been proven to provide very significant overall health benefits. The consumption of red wine is an integral part of the Mediterranean diet, found to be extraordinarily health promoting. It is in red wine and peanuts that resveratrol is found in nature, suggesting that this is how nature intended for us to consume it. When any compound is part of a whole food, it is a part of a complex of balanced compounds that give it an integrity not found when it appears as an isolated extract.

Additional reference:

Melissa Q.B.McElderry, M.S., R.D., “Grape Expectations: The Resveratrol Story”.

Red Wine’s Resveratrol May Help Battle Obesity

by Leslee Dru Browning (see all articles by this author)

(NaturalNews) Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study. The results will be presented at The Endocrine Society’s 90th Annual Meeting in San Francisco .

Past research found that resveratrol protected laboratory mice that were fed a high-calorie diet from the health problems of obesity, by mimicking the effects of calorie restriction. Researchers at the University of Ulm in Germany wanted to know if resveratrol could mimic the effects of calorie restriction in human fat cells by changing their size or function. The German team used a strain of human fat cell precursors, called preadipocytes. In the body, these cells develop into mature fat cells, according to the study’s lead author, Pamela Fischer-Posovszky, PhD, a pediatric endocrinology research fellow in the university’s Diabetes and Obesity Unit.

In the cell-based study, they found that resveratrol inhibited the pre-fat cells from increasing and prevented them from converting into mature fat cells. Also, resveratrol hindered fat storage. Most interesting, according to Fischer-Posovszky, was that resveratrol reduced production of certain cytokines (interleukins 6 and 8), substances that may be linked to the development of obesity-related disorders, such as diabetes and clogged coronary arteries. Also, resveratrol stimulated formation of a protein known to decrease the risk of heart attack. Obesity decreases this substance, called adiponectin.

The new finding is consistent with the theory that the resveratrol in red wine explains the French paradox, the observation that French people eat a relatively high-fat diet but have a low death rate from heart disease.

“Resveratrol has anti-obesity properties by exerting its effects directly on the fat cells,” Fischer-Posovszky said. “Thus, resveratrol might help to prevent development of obesity or might be suited to treating obesity.”

Fischer-Posovszky cautioned that, while the health benefits of resveratrol seem promising, there is not sufficient knowledge about the effects of long-term treatment. One small study found that a single dose of up to 5 grams of resveratrol (much higher than the amount in a bottle of red wine) caused no serious ill effects in healthy volunteers, she pointed out. However, she said another study theorized that resveratrol may stimulate the growth of human breast cancer cells, possibly because resveratrol’s chemical structure is similar to a phytoestrogen, an estrogen-like substance found in some plants.

This study was partly funded by the German Research Association (Deutsche Forschungsgemeinschaft) and the Ministry of Science, Research and Arts (Ministerium fuer Wissenschaft, Forschung und Kunst), Baden-Wuerttemberg.

Source:

Newswise: (http://www.newswise.com:80/)

The Endocrine Society: (http://www.endo-society.org)
Founded in 1916, The Endocrine Society is the world’s oldest, largest, and most active organization devoted to research on hormones, and the clinical practice of endocrinology. Today, The Endocrine Society’s membership consists of over 14,000 scientists, physicians, educators, nurses and students in more than 80 countries. Together, these members represent all basic, applied, and clinical interests in endocrinology.

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New Study Reveals Resveratrol Improves Health and Longevity

by Dr. Phil Domenico (see all articles by this author)

(NaturalNews) Such important information should not be downplayed by the mass media. Yet, that is exactly what just transpired. Instead, they reported that resveratrol improved health, but not longevity, in aging mice on a standard diet. In other words, they chose not to report the most important outcome from the study.

I hate to be a conspiracy theorist, or think that news from the prestigious National Institutes of Health could be so cynical and distorted. Either someone doesn’t understand the essence of this study, or does not want other people to know about it. Unfortunately, the latter is likely closer to the truth. It has become abundantly clear that those in power do not want people to know that a simple antioxidant contained in many foods and supplements can have such powerful health effects. And, if resveratrol can truly reverse the ravages of a poor diet, and enhance longevity in those who are overweight, Big Pharma will want to have complete control over it.

Apparently, they already have control over the mass media. How else could such an important story go untold? With most people in America overweight, similar to the mice in the high-calorie group, how could this not be front page news? For those of you who don’t get it, the connection between the pharmaceutical industry and mass media is simple and straightforward. Unfortunately, the press can be bought, and Big Pharma has an enormous amount of capital expressly for these purposes. Money talks.

This study was the result of an extensive collaboration between Rafael de Cabo, Ph.D. at the National Institute on Aging (NIA), David A. Sinclair, Ph.D. at Harvard Medical School , and 13 other institutions globally. Their findings were published in the July 3rd, 2008 issue of Cell Metabolism. The researchers showed that resveratrol prevented age- and obesity-related decline in cardiovascular function in older mice, as determined by several parameters. Total cholesterol and inflammation was significantly reduced and blood vessels functioned significantly better in the treated mice. Treated mice also tended to have better bone health, reduced cataract formation, and enhanced balance and motor coordination, whether on a standard or a high-calorie diet. All this from the key ingredient in red wine that protects cheese-eating Frenchies from heart disease.

However, the highlight of the study was about longevity. That’s the real promise of resveratrol, but apparently only for mice on a high-calorie diet. The researchers speculated that improved cardiovascular health and reduced fatty changes in the liver were contributing factors.

Resveratrol has been shown to enhance longevity in worms and fruit flies, but this current study supports the effect in mammals. In fact, a smaller mouse study was performed in 2006 with a similar outcome. In the prior study, resveratrol produced changes associated with longer lifespan, including improved insulin function, increased mitochondrial number, and improved motor function. Resveratrol canceled out the ill effects of a high-calorie diet in 144 of 153 activated genes. The data imply that it is possible to improve health simply by taking a pill; not one of those expensive drugs with a host of negative side effects, but one containing a promising antioxidant found in many foods that promote health. For most, drinking red wine may be preferable to popping pills. Yet, much more resveratrol can be concentrated in supplements, and it is likely that many glasses of wine will be required for maximum benefits. Hopefully, one day the optimum dose will be added to the wine so that one or two servings will do the trick.

Granted, these findings are based on mice, not humans. Furthermore, the overweight mice in these studies did not necessarily lose weight. Nevertheless, they were able to enjoy a high-calorie diet and live substantially longer. How can you beat that? Moreover, it is possible to be overweight and still be relatively healthy. Given the current obesity epidemic among humans, what a difference resveratrol could make. It does not replace good, old-fashioned discipline in diet and exercise, but it would be a great start to help reduce healthcare costs under the current conditions.

There are still many questions remaining about safety, dosing and clinical efficacy before resveratrol can be recommended for human use. That being said, let’s hope that Big Pharma doesn’t continue to stall awareness of health issues for the sake of profit, or to find a way to squelch this research altogether.

Reference:

Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342.

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